Antagonistic Effect of Low-dose Liquiritigenin on Gemcitabine-induced Capillary Leak Syndrome
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چکیده
Gemcitabine (Gemcitabine), a synthetic pyrimidine nucleoside, could block DNA synthesis and inhibit RNA synthesis to some extent. It is used as the standard chemotherapy for pancreatic adenocarcinoma in stage II, III and IV, although it’s primarily palliative (Lau et al., 2012). As a severe result of the attack by gemcitabineinduced cytotoxicity for capillary endothelial cells (CECs), capillary leak syndrome (CLS) has been reported in several cases (De Pas et al., 2001; Pulkkanen et al., 2003; Biswas et al., 2004; Dahan et al., 2007). CLS, a serious disorder characterized by capillary hyperpermeability and albumin leak, is initiated by damaging CECs and their conjunctions that lead to RESEARCH ARTICLE
منابع مشابه
Gemcitabine-induced chronic systemic capillary leak syndrome
A 56-year-old woman presented with anasarca, hypoalbuminaemia and hypotension following cycle 3 day 1 of adjuvant gemcitabine for stage II pancreatic cancer. Due to the temporal nature of presentation, suspicion for gemcitabine-induced capillary leak syndrome was included in the differential diagnosis. Vascular endothelial growth factor levels were elevated at 707 pg/mL (reference range: 9-86 p...
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